METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth

Recently, covalent modifications of RNA, such as methylation, have emerged as key regulators of all aspects of RNA biology and have been implicated in numerous diseases, for instance, cancer. Here, we undertook a combination of in vitro and in vivo screens to test 78 potential methyltransferases for...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Ignatova, Valentina V., Kaiser, Steffen, Ho, Jessica Sook Yuin, Bing, Xinyang, Stolz, Paul, Tan, Ying Xim, Lee, Chee Leng, Gay, Florence Pik Hoon, Lastres, Palma Rico, Gerlini, Raffaele, Rathkolb, Birgit, Aguilar-Pimentel, Antonio, Sanz-Moreno, Adrián, Klein-Rodewald, Tanja, Calzada-Wack, Julia, Ibragimov, Emil, Valenta, Magdalena, Lukauskas, Saulius, Pavesi, Andrea, Marschall, Susan, Leuchtenberger, Stefanie, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabe, Bultmann, Sebastian, Rando, Oliver J., Guccione, Ernesto, Kellner, Stefanie M., Schneider, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449687/
https://ncbi.nlm.nih.gov/pubmed/32923617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4551
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