METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth

Recently, covalent modifications of RNA, such as methylation, have emerged as key regulators of all aspects of RNA biology and have been implicated in numerous diseases, for instance, cancer. Here, we undertook a combination of in vitro and in vivo screens to test 78 potential methyltransferases for...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Ignatova, Valentina V., Kaiser, Steffen, Ho, Jessica Sook Yuin, Bing, Xinyang, Stolz, Paul, Tan, Ying Xim, Lee, Chee Leng, Gay, Florence Pik Hoon, Lastres, Palma Rico, Gerlini, Raffaele, Rathkolb, Birgit, Aguilar-Pimentel, Antonio, Sanz-Moreno, Adrián, Klein-Rodewald, Tanja, Calzada-Wack, Julia, Ibragimov, Emil, Valenta, Magdalena, Lukauskas, Saulius, Pavesi, Andrea, Marschall, Susan, Leuchtenberger, Stefanie, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabe, Bultmann, Sebastian, Rando, Oliver J., Guccione, Ernesto, Kellner, Stefanie M., Schneider, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449687/
https://ncbi.nlm.nih.gov/pubmed/32923617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4551
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