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Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases

N(6)-methyladenosine (m(6)A) is a prevalent, reversible chemical modification of functional RNAs, and is important for central events in biology. The core m(6)A writers are Mettl3 and Mettl14, which both contain methyltransferase domains. How Mettl3 and Mettl14 cooperate to catalyze methylation of a...

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Vydáno v:Mol Cell
Hlavní autoři: Wang, Ping, Doxtader, Katelyn A., Nam, Yunsun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958592/
https://ncbi.nlm.nih.gov/pubmed/27373337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.041
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