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Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases

N(6)-methyladenosine (m(6)A) is a prevalent, reversible chemical modification of functional RNAs, and is important for central events in biology. The core m(6)A writers are Mettl3 and Mettl14, which both contain methyltransferase domains. How Mettl3 and Mettl14 cooperate to catalyze methylation of a...

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Publicat a:Mol Cell
Autors principals: Wang, Ping, Doxtader, Katelyn A., Nam, Yunsun
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958592/
https://ncbi.nlm.nih.gov/pubmed/27373337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.041
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