Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase

N(6)-methyladenosine (m(6)A), a ubiquitous RNA modification, is installed by METTL3-METTL14 complex. The structure of the heterodimeric complex between the methyltransferase domains (MTDs) of METTL3 and METTL14 has been previously determined. However, the MTDs alone possess no enzymatic activity. He...

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Pubblicato in:Protein Cell
Autori principali: Huang, Jinbo, Dong, Xu, Gong, Zhou, Qin, Ling-Yun, Yang, Shuai, Zhu, Yue-Ling, Wang, Xiang, Zhang, Delin, Zou, Tingting, Yin, Ping, Tang, Chun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Higher Education Press 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418081/
https://ncbi.nlm.nih.gov/pubmed/29542011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-018-0518-7
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