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Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases

N(6)-methyladenosine (m(6)A) is a prevalent, reversible chemical modification of functional RNAs, and is important for central events in biology. The core m(6)A writers are Mettl3 and Mettl14, which both contain methyltransferase domains. How Mettl3 and Mettl14 cooperate to catalyze methylation of a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Wang, Ping, Doxtader, Katelyn A., Nam, Yunsun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958592/
https://ncbi.nlm.nih.gov/pubmed/27373337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.05.041
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