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Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance

Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant Mycobacterium tuberculosis mutants derived from four M. tuberculosis strains. These LGDs had no growth defect in vitro but could be defective in intracellular growth and showed various sensitivities toward oxidative st...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Vilchèze, Catherine, Saranathan, Rajagopalan, Weinrick, Brian, Jacobs, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449219/
https://ncbi.nlm.nih.gov/pubmed/32631825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00792-20
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