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Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance

Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant Mycobacterium tuberculosis mutants derived from four M. tuberculosis strains. These LGDs had no growth defect in vitro but could be defective in intracellular growth and showed various sensitivities toward oxidative st...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Vilchèze, Catherine, Saranathan, Rajagopalan, Weinrick, Brian, Jacobs, William R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449219/
https://ncbi.nlm.nih.gov/pubmed/32631825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00792-20
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