How To Optimally Combine Genotypic and Phenotypic Drug Susceptibility Testing Methods for Pyrazinamide

False-susceptible phenotypic drug-susceptibility testing (DST) results for pyrazinamide due to mutations with MICs close to the critical concentration (CC) confound the classification of pncA resistance mutations, leading to an underestimate of the specificity of genotypic DST. This could be minimiz...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Köser, Claudio U., Cirillo, Daniela M., Miotto, Paolo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449218/
https://ncbi.nlm.nih.gov/pubmed/32571824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01003-20
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