Isoniazid Resistance in Mycobacterium tuberculosis Is a Heterogeneous Phenotype Composed of Overlapping MIC Distributions with Different Underlying Resistance Mechanisms

MIC testing using the Bactec mycobacteria growth indicator tube system 960 of 70 phylogenetically diverse, isoniazid-resistant clinical strains of Mycobacterium tuberculosis revealed a complex pattern of overlapping MIC distributions. Whole-genome sequencing explained most of the levels of resistanc...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Ghodousi, Arash, Tagliani, Elisa, Karunaratne, Eranga, Niemann, Stefan, Perera, Jennifer, Köser, Claudio U., Cirillo, Daniela Maria
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591585/
https://ncbi.nlm.nih.gov/pubmed/31010866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00092-19
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