Comparison of Phenotypic and Genotypic Methods for Pyrazinamide Susceptibility Testing with Mycobacterium tuberculosis

Mycobacterium tuberculosis converts pyrazinamide to its active form by using the enzyme pyrazinamidase. This enzyme is coded for on the pncA gene, and mutations in the pncA gene result in absence of active enzyme, conferring resistance to the drug pyrazinamide. We investigated 27 strains of Mycobact...

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Hauptverfasser: Davies, A. P., Billington, O. J., McHugh, T. D., Mitchison, D. A., Gillespie, S. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Mycobacteriology and Aerobic Actinomycetes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC87457/
https://ncbi.nlm.nih.gov/pubmed/11015384
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