Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer

PURPOSE: Patterns of resistance to first-line osimertinib are not well-established and have primarily been evaluated using plasma assays which cannot detect histologic transformation and have differential sensitivity for copy number changes and chromosomal rearrangements. EXPERIMENTAL DESIGN: To cha...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Schoenfeld, Adam J., Chan, Joseph M., Kubota, Daisuke, Sato, Hiroki, Rizvi, Hira, Daneshbod, Yahya, Chang, Jason, Paik, Paul K., Offin, Michael, Arcila, Maria E., Davare, Monika A., Shinde, Ujwal, Pe’er, Dana, Rekhtman, Natasha, Kris, Mark G., Somwar, Romel, Riely, Gregory J., Ladanyi, Marc, Yu, Helena A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448565/
https://ncbi.nlm.nih.gov/pubmed/31911548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-3563
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados