Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes

INTRODUCTION: EGFR-mutant lung cancers are clinically and genomically heterogeneous with concurrent RB1/TP53 alterations identifying a subset at increased risk for small cell transformation. The genomic alterations that induce lineage plasticity are unknown. METHODS: Patients with EGFR/RB1/TP53-muta...

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Vydáno v:J Thorac Oncol
Hlavní autoři: Offin, Michael, Chan, Joseph M., Tenet, Megan, Rizvi, Hira A., Shen, Ronglai, Riely, Gregory J., Rekhtman, Natasha, Daneshbod, Yahya, Quintanal-Villalonga, Alvaro, Penson, Alexander, Hellmann, Matthew D., Arcila, Maria E., Ladanyi, Marc, Pe’er, Dana, Kris, Mark G., Rudin, Charles M., Yu, Helena A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764905/
https://ncbi.nlm.nih.gov/pubmed/31228622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2019.06.002
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