Endometrial Cancers in BRCA1 or BRCA2 Germline Mutation Carriers: Assessment of Homologous Recombination DNA Repair Defects

PURPOSE: Endometrial cancer (EC) is not considered a component of the hereditary breast and ovarian cancer syndrome but can arise in patients with germline BRCA1/2 (gBRCA1/2) mutations. Biallelic BRCA1/2 alterations are associated with genomic features of homologous recombination DNA repair deficien...

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Udgivet i:JCO Precis Oncol
Main Authors: Smith, Evan S., Da Cruz Paula, Arnaud, Cadoo, Karen A., Abu-Rustum, Nadeem R., Pei, Xin, Brown, David N., Ferrando, Lorenzo, Sebastiao, Ana Paula Martins, Riaz, Nadeem, Robson, Mark E., Soslow, Robert A., Reis-Filho, Jorge S., Mandelker, Diana, Weigelt, Britta
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2019
Fag:
Original Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446423/
https://ncbi.nlm.nih.gov/pubmed/32914019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00103
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