BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-associated tumors respond. Herein we report analyses of 160 BRCA1 and BRCA2 germline mutation-associated breast and ovarian tumors. Retention of the norm...

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Publicado no:Nat Commun
Main Authors: Maxwell, Kara N., Wubbenhorst, Bradley, Wenz, Brandon M., De Sloover, Daniel, Pluta, John, Emery, Lyndsey, Barrett, Amanda, Kraya, Adam A., Anastopoulos, Ioannis N., Yu, Shun, Jiang, Yuchao, Chen, Hao, Zhang, Nancy R., Hackman, Nicole, D’Andrea, Kurt, Daber, Robert, Morrissette, Jennifer J. D., Mitra, Nandita, Feldman, Michael, Domchek, Susan M., Nathanson, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567274/
https://ncbi.nlm.nih.gov/pubmed/28831036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00388-9
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