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BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-associated tumors respond. Herein we report analyses of 160 BRCA1 and BRCA2 germline mutation-associated breast and ovarian tumors. Retention of the norm...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567274/ https://ncbi.nlm.nih.gov/pubmed/28831036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00388-9 |
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