BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-associated tumors respond. Herein we report analyses of 160 BRCA1 and BRCA2 germline mutation-associated breast and ovarian tumors. Retention of the norm...

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書誌詳細
出版年:Nat Commun
主要な著者: Maxwell, Kara N., Wubbenhorst, Bradley, Wenz, Brandon M., De Sloover, Daniel, Pluta, John, Emery, Lyndsey, Barrett, Amanda, Kraya, Adam A., Anastopoulos, Ioannis N., Yu, Shun, Jiang, Yuchao, Chen, Hao, Zhang, Nancy R., Hackman, Nicole, D’Andrea, Kurt, Daber, Robert, Morrissette, Jennifer J. D., Mitra, Nandita, Feldman, Michael, Domchek, Susan M., Nathanson, Katherine L.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567274/
https://ncbi.nlm.nih.gov/pubmed/28831036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00388-9
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