Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer

PURPOSE: Breast cancers with BRCA1/2 alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely and molecular features contributing to this variability remain unknow...

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Publicado no:Clin Cancer Res
Main Authors: Kraya, Adam A., Maxwell, Kara N., Wubbenhorst, Bradley, Wenz, Brandon M., Pluta, John, Rech, Andrew J., Dorfman, Liza M., Lunceford, Nicole, Barrett, Amanda, Mitra, Nandita, Morrissette, Jennifer J.D., Feldman, Michael, Nayak, Anupma, Domchek, Susan M., Vonderheide, Robert H., Nathanson, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635013/
https://ncbi.nlm.nih.gov/pubmed/30914433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0468
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