Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer

PURPOSE: Breast cancers with BRCA1/2 alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely and molecular features contributing to this variability remain unknow...

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Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Kraya, Adam A., Maxwell, Kara N., Wubbenhorst, Bradley, Wenz, Brandon M., Pluta, John, Rech, Andrew J., Dorfman, Liza M., Lunceford, Nicole, Barrett, Amanda, Mitra, Nandita, Morrissette, Jennifer J.D., Feldman, Michael, Nayak, Anupma, Domchek, Susan M., Vonderheide, Robert H., Nathanson, Katherine L.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635013/
https://ncbi.nlm.nih.gov/pubmed/30914433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0468
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