Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer

PURPOSE: Breast cancers with BRCA1/2 alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely and molecular features contributing to this variability remain unknow...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Kraya, Adam A., Maxwell, Kara N., Wubbenhorst, Bradley, Wenz, Brandon M., Pluta, John, Rech, Andrew J., Dorfman, Liza M., Lunceford, Nicole, Barrett, Amanda, Mitra, Nandita, Morrissette, Jennifer J.D., Feldman, Michael, Nayak, Anupma, Domchek, Susan M., Vonderheide, Robert H., Nathanson, Katherine L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635013/
https://ncbi.nlm.nih.gov/pubmed/30914433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0468
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