Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer

PURPOSE: Breast cancers with BRCA1/2 alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely and molecular features contributing to this variability remain unknow...

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Publicat a:Clin Cancer Res
Autors principals: Kraya, Adam A., Maxwell, Kara N., Wubbenhorst, Bradley, Wenz, Brandon M., Pluta, John, Rech, Andrew J., Dorfman, Liza M., Lunceford, Nicole, Barrett, Amanda, Mitra, Nandita, Morrissette, Jennifer J.D., Feldman, Michael, Nayak, Anupma, Domchek, Susan M., Vonderheide, Robert H., Nathanson, Katherine L.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635013/
https://ncbi.nlm.nih.gov/pubmed/30914433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0468
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