Genomic signatures predict the immunogenicity of BRCA-deficient breast cancer

PURPOSE: Breast cancers with BRCA1/2 alterations have a relatively high mutational load, suggesting that immune checkpoint blockade may be a potential treatment option. However, the degree of immune cell infiltration varies widely and molecular features contributing to this variability remain unknow...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Kraya, Adam A., Maxwell, Kara N., Wubbenhorst, Bradley, Wenz, Brandon M., Pluta, John, Rech, Andrew J., Dorfman, Liza M., Lunceford, Nicole, Barrett, Amanda, Mitra, Nandita, Morrissette, Jennifer J.D., Feldman, Michael, Nayak, Anupma, Domchek, Susan M., Vonderheide, Robert H., Nathanson, Katherine L.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635013/
https://ncbi.nlm.nih.gov/pubmed/30914433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0468
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