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Neoantigen dissimilarity to the self-proteome predicts immunogenicity and response to immune checkpoint blockade

Despite improved methods for MHC affinity prediction, the vast majority of computationally predicted tumor neoantigens are not immunogenic experimentally, indicating that high-quality neoantigens are beyond current algorithms to discern. To enrich for neoantigens with the greatest likelihood of immu...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Richman, Lee P., Vonderheide, Robert H., Rech, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813910/
https://ncbi.nlm.nih.gov/pubmed/31606370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.08.009
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