Analysis of mutational signatures in primary and metastatic endometrial cancer reveals distinct patterns of DNA repair defects and shifts during tumor progression

OBJECTIVE: Mutational signatures provide insights into the biological processes shaping tumor genomes and may inform patient therapy. We sought to define the mutational signatures of i) endometrioid and serous endometrial carcinomas (ECs), stratified into the four molecular subtypes, ii) uterine car...

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Detalhes bibliográficos
Publicado no:Gynecol Oncol
Main Authors: Ashley, Charles W., Da Cruz Paula, Arnaud, Kumar, Rahul, Mandelker, Diana, Pei, Xin, Riaz, Nadeem, Reis-Filho, Jorge S, Weigelt, Britta
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726428/
https://ncbi.nlm.nih.gov/pubmed/30415991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2018.10.032
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