Analysis of mutational signatures in primary and metastatic endometrial cancer reveals distinct patterns of DNA repair defects and shifts during tumor progression

OBJECTIVE: Mutational signatures provide insights into the biological processes shaping tumor genomes and may inform patient therapy. We sought to define the mutational signatures of i) endometrioid and serous endometrial carcinomas (ECs), stratified into the four molecular subtypes, ii) uterine car...

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Vydáno v:Gynecol Oncol
Hlavní autoři: Ashley, Charles W., Da Cruz Paula, Arnaud, Kumar, Rahul, Mandelker, Diana, Pei, Xin, Riaz, Nadeem, Reis-Filho, Jorge S, Weigelt, Britta
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726428/
https://ncbi.nlm.nih.gov/pubmed/30415991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2018.10.032
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