Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

BRCA1 and BRCA2 are involved in homologous recombination (HR) DNA repair and are germ-line cancer pre-disposition genes that result in a syndrome of hereditary breast and ovarian cancer (HBOC). Whether germ-line or somatic alterations in these genes or other members of the HR pathway and if mono- or...

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發表在:Nat Commun
Main Authors: Riaz, Nadeem, Blecua, Pedro, Lim, Raymond S., Shen, Ronglai, Higginson, Daniel S., Weinhold, Nils, Norton, Larry, Weigelt, Britta, Powell, Simon N., Reis-Filho, Jorge S.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636842/
https://ncbi.nlm.nih.gov/pubmed/29021619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00921-w
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