Bi-allelic alterations in DNA repair genes underpin Homologous recombination DNA repair defects in breast cancer

Homologous recombination (HR) DNA repair deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence suggests that sporadic breast cancers, lacking germline BRCA1/BRCA2 mutations, may also be HRD. We developed a functional ex-vivo RAD51-based...

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Bibliografski detalji
Izdano u:J Pathol
Glavni autori: Mutter, Robert W., Riaz, Nadeem, Ng, Charlotte K. Y., Delsite, Rob, Piscuoglio, Salvatore, Edelweiss, Marcia, Martelotto, Luciano G., Sakr, Rita A., King, Tari A., Giri, Dilip D., Drobnjak, Maria, Brogi, Edi, Bindra, Ranjit, Bernheim, Giana, Lim, Raymond S., Blecua, Pedro, Desrichard, Alexis, Higginson, Dan, Towers, Russell, Jiang, Ruomu, Lee, William, Weigelt, Britta, Reis-Filho, Jorge S., Powell, Simon N.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516531/
https://ncbi.nlm.nih.gov/pubmed/28299801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4890
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