DNA repair and synthetic lethality

Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thu...

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Autors principals: Guo, Gong-she, Zhang, Feng-mei, Gao, Rui-jie, Delsite, Robert, Feng, Zhi-hui, Powell, Simon N
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469974/
https://ncbi.nlm.nih.gov/pubmed/22010575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4248/IJOS11064
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