DNA repair and synthetic lethality

Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thu...

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Main Authors: Guo, Gong-she, Zhang, Feng-mei, Gao, Rui-jie, Delsite, Robert, Feng, Zhi-hui, Powell, Simon N
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469974/
https://ncbi.nlm.nih.gov/pubmed/22010575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4248/IJOS11064
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