Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(Macro)autophagy delivers cellular constituents to lysosomes for degradation. Although a cytoplasmic process, autophagy-deficient cells accumulate genomic damage, but an explanation for this effect is currently unclear. We report here that inhibition of autophagy causes elevated proteasomal activity...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Liu, Emma Y., Xu, Naihan, O’Prey, Jim, Lao, Laurence Y., Joshi, Sanket, Long, Jaclyn S., O’Prey, Margaret, Croft, Daniel R., Beaumatin, Florian, Baudot, Alice D., Mrschtik, Michaela, Rosenfeldt, Mathias, Zhang, Yaou, Gillespie, David A., Ryan, Kevin M.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311830/
https://ncbi.nlm.nih.gov/pubmed/25568088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409563112
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