Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(Macro)autophagy delivers cellular constituents to lysosomes for degradation. Although a cytoplasmic process, autophagy-deficient cells accumulate genomic damage, but an explanation for this effect is currently unclear. We report here that inhibition of autophagy causes elevated proteasomal activity...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Emma Y., Xu, Naihan, O’Prey, Jim, Lao, Laurence Y., Joshi, Sanket, Long, Jaclyn S., O’Prey, Margaret, Croft, Daniel R., Beaumatin, Florian, Baudot, Alice D., Mrschtik, Michaela, Rosenfeldt, Mathias, Zhang, Yaou, Gillespie, David A., Ryan, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311830/
https://ncbi.nlm.nih.gov/pubmed/25568088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409563112
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