Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(Macro)autophagy delivers cellular constituents to lysosomes for degradation. Although a cytoplasmic process, autophagy-deficient cells accumulate genomic damage, but an explanation for this effect is currently unclear. We report here that inhibition of autophagy causes elevated proteasomal activity...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Liu, Emma Y., Xu, Naihan, O’Prey, Jim, Lao, Laurence Y., Joshi, Sanket, Long, Jaclyn S., O’Prey, Margaret, Croft, Daniel R., Beaumatin, Florian, Baudot, Alice D., Mrschtik, Michaela, Rosenfeldt, Mathias, Zhang, Yaou, Gillespie, David A., Ryan, Kevin M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311830/
https://ncbi.nlm.nih.gov/pubmed/25568088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409563112
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares