Bi-allelic alterations in DNA repair genes underpin Homologous recombination DNA repair defects in breast cancer

Homologous recombination (HR) DNA repair deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence suggests that sporadic breast cancers, lacking germline BRCA1/BRCA2 mutations, may also be HRD. We developed a functional ex-vivo RAD51-based...

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Udgivet i:J Pathol
Main Authors: Mutter, Robert W., Riaz, Nadeem, Ng, Charlotte K. Y., Delsite, Rob, Piscuoglio, Salvatore, Edelweiss, Marcia, Martelotto, Luciano G., Sakr, Rita A., King, Tari A., Giri, Dilip D., Drobnjak, Maria, Brogi, Edi, Bindra, Ranjit, Bernheim, Giana, Lim, Raymond S., Blecua, Pedro, Desrichard, Alexis, Higginson, Dan, Towers, Russell, Jiang, Ruomu, Lee, William, Weigelt, Britta, Reis-Filho, Jorge S., Powell, Simon N.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516531/
https://ncbi.nlm.nih.gov/pubmed/28299801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4890
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