PTEN Loss-of-Function Alterations Are Associated With Intrinsic Resistance to BRAF Inhibitors in Metastatic Melanoma

PURPOSE: The clinical use of BRAF inhibitors in patients with melanoma is limited by intrinsic and acquired resistance. We asked whether next-generation sequencing of pretreatment tumors could identify coaltered genes that predict for intrinsic resistance to BRAF inhibitor therapy in patients with m...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Catalanotti, Federica, Cheng, Donavan T., Shoushtari, Alexander N., Johnson, Douglas B., Panageas, Katherine S., Momtaz, Parisa, Higham, Catherine, Won, Helen H., Harding, James J., Merghoub, Taha, Rosen, Neal, Sosman, Jeffrey A., Berger, Michael F., Chapman, Paul B., Solit, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2017
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446400/
https://ncbi.nlm.nih.gov/pubmed/32913971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.16.00054
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