Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells

The mechanisms by which some melanoma cells adapt to BRAF inhibitor therapy are incompletely understood. In the present study, we used mass spectrometry-based phosphoproteomics to determine how BRAF inhibition remodeled the signaling network of melanoma cell lines that were BRAF-mutant and PTEN-null...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Fedorenko, Inna V., Abel, Ethan V., Koomen, John M., Fang, Bin, Wood, Elizabeth R., Chen, Y. Ann, Fisher, Kate J., Iyengar, Sanjana, Dahlman, Kimberly B., Wargo, Jennifer A., Flaherty, Keith T., Sosman, Jeffrey A., Sondak, Vernon K., Messina, Jane L., Gibney, Geoffrey T., Smalley, Keiran S.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679729/
https://ncbi.nlm.nih.gov/pubmed/26073081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.188
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