PTEN Loss-of-Function Alterations Are Associated With Intrinsic Resistance to BRAF Inhibitors in Metastatic Melanoma

PURPOSE: The clinical use of BRAF inhibitors in patients with melanoma is limited by intrinsic and acquired resistance. We asked whether next-generation sequencing of pretreatment tumors could identify coaltered genes that predict for intrinsic resistance to BRAF inhibitor therapy in patients with m...

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發表在:JCO Precis Oncol
Main Authors: Catalanotti, Federica, Cheng, Donavan T., Shoushtari, Alexander N., Johnson, Douglas B., Panageas, Katherine S., Momtaz, Parisa, Higham, Catherine, Won, Helen H., Harding, James J., Merghoub, Taha, Rosen, Neal, Sosman, Jeffrey A., Berger, Michael F., Chapman, Paul B., Solit, David B.
格式: Artigo
語言:Inglês
出版: American Society of Clinical Oncology 2017
主題:
Original Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446400/
https://ncbi.nlm.nih.gov/pubmed/32913971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.16.00054
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