Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia

BACKGROUND: Artemisinin resistance is threatening malaria control. We aimed to develop and test a human model of artemisinin-resistant (ART-R) Plasmodium falciparum to evaluate the efficacy of drugs against ART-R malaria. METHODS AND FINDINGS: We conducted 2 sequential phase 1, single-centre, open-l...

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Vydáno v:PLoS Med
Hlavní autoři: Watts, Rebecca E., Odedra, Anand, Marquart, Louise, Webb, Lachlan, Abd-Rahman, Azrin N., Cascales, Laura, Chalon, Stephan, Rebelo, Maria, Pava, Zuleima, Collins, Katharine A., Pasay, Cielo, Chen, Nanhua, Peatey, Christopher L., Möhrle, Jörg J., McCarthy, James S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444516/
https://ncbi.nlm.nih.gov/pubmed/32822347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003203
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