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Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery
Rapid clearance by renal filtration is a major impediment to the translation of small bioactive biologics into drugs. To extend serum t(1/2), a commonly used approach is to attach drug leads to the G-related albumin-binding domain (ABD) to bind albumin and evade clearance. Despite the success of thi...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443490/ https://ncbi.nlm.nih.gov/pubmed/32647013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014168 |
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