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Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain

The therapeutic and diagnostic efficiency of engineered small proteins, peptides, and chemical drug candidates is hampered by short in vivo serum half-life. Thus, strategies to tailor their biodistribution and serum persistence are highly needed. An attractive approach is to take advantage of the ex...

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Bibliografiska uppgifter
Huvudupphovsmän: Andersen, Jan Terje, Pehrson, Rikard, Tolmachev, Vladimir, Daba, Muluneh Bekele, Abrahmsén, Lars, Ekblad, Caroline
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037636/
https://ncbi.nlm.nih.gov/pubmed/21138843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164848
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