TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma

BACKGROUND: The ligands of mitochondrial translocator protein (TSPO) have been widely used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in vivo and its role in glioma tumorigenesis remain elusive. METHODS: TSPO knockout xenograft and spontaneous mouse glioma mode...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Fu, Yi, Wang, Dongdong, Wang, Huaishan, Cai, Menghua, Li, Chao, Zhang, Xue, Chen, Hui, Hu, Yu, Zhang, Xuan, Ying, Mingyao, He, Wei, Zhang, Jianmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442372/
https://ncbi.nlm.nih.gov/pubmed/31563962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz183
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