Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma

BACKGROUND: Glioblastoma survival remains unchanged despite continuing therapeutic innovation. Herein, we aim to (i) develop chimeric antigen receptor (CAR) T cells with a specificity to a unique antigen, carbonic anhydrase IX (CAIX), which is expressed in the hypoxic microenvironment characteristic...

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發表在:Neuro Oncol
Main Authors: Cui, Jing, Zhang, Qi, Song, Qi, Wang, Herui, Dmitriev, Pauline, Sun, Mitchell Y, Cao, Xiaoyu, Wang, Yang, Guo, Liemei, Indig, Iris H, Rosenblum, Jared S, Ji, Chunxia, Cao, Dongqing, Yang, Kaiyong, Gilbert, Mark R, Yao, Yu, Zhuang, Zhengping
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
主題:
Basic and Translational Investigations
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827823/
https://ncbi.nlm.nih.gov/pubmed/31276594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz117
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