TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma

BACKGROUND: The ligands of mitochondrial translocator protein (TSPO) have been widely used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in vivo and its role in glioma tumorigenesis remain elusive. METHODS: TSPO knockout xenograft and spontaneous mouse glioma mode...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Fu, Yi, Wang, Dongdong, Wang, Huaishan, Cai, Menghua, Li, Chao, Zhang, Xue, Chen, Hui, Hu, Yu, Zhang, Xuan, Ying, Mingyao, He, Wei, Zhang, Jianmin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2020
Ämnen:
Basic and Translational Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442372/
https://ncbi.nlm.nih.gov/pubmed/31563962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz183
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