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TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma

BACKGROUND: The ligands of mitochondrial translocator protein (TSPO) have been widely used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in vivo and its role in glioma tumorigenesis remain elusive. METHODS: TSPO knockout xenograft and spontaneous mouse glioma mode...

詳細記述

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書誌詳細
出版年:Neuro Oncol
主要な著者: Fu, Yi, Wang, Dongdong, Wang, Huaishan, Cai, Menghua, Li, Chao, Zhang, Xue, Chen, Hui, Hu, Yu, Zhang, Xuan, Ying, Mingyao, He, Wei, Zhang, Jianmin
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442372/
https://ncbi.nlm.nih.gov/pubmed/31563962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz183
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