The angiogenic switch leads to a metabolic shift in human glioblastoma

BACKGROUND. Invasion and angiogenesis are major hallmarks of glioblastoma (GBM) growth. While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells within neovascularized regions exhibit hypoxic stress and promote angiogenesis. The distinct microenvironments likely...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Talasila, Krishna M., Røsland, Gro V., Hagland, Hanne R., Eskilsson, Eskil, Flønes, Irene H., Fritah, Sabrina, Azuaje, Francisco, Atai, Nadia, Harter, Patrick N., Mittelbronn, Michel, Andersen, Michael, Joseph, Justin V., Hossain, Jubayer Al, Vallar, Laurent, van Noorden, Cornelis J. F., Niclou, Simone P., Thorsen, Frits, Tronstad, Karl Johan, Tzoulis, Charalampos, Bjerkvig, Rolf, Miletic, Hrvoje
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464376/
https://ncbi.nlm.nih.gov/pubmed/27591677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now175
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