The angiogenic switch leads to a metabolic shift in human glioblastoma

BACKGROUND. Invasion and angiogenesis are major hallmarks of glioblastoma (GBM) growth. While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells within neovascularized regions exhibit hypoxic stress and promote angiogenesis. The distinct microenvironments likely...

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Pubblicato in:Neuro Oncol
Autori principali: Talasila, Krishna M., Røsland, Gro V., Hagland, Hanne R., Eskilsson, Eskil, Flønes, Irene H., Fritah, Sabrina, Azuaje, Francisco, Atai, Nadia, Harter, Patrick N., Mittelbronn, Michel, Andersen, Michael, Joseph, Justin V., Hossain, Jubayer Al, Vallar, Laurent, van Noorden, Cornelis J. F., Niclou, Simone P., Thorsen, Frits, Tronstad, Karl Johan, Tzoulis, Charalampos, Bjerkvig, Rolf, Miletic, Hrvoje
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464376/
https://ncbi.nlm.nih.gov/pubmed/27591677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now175
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