AI-10 DISTINCT EGFR SIGNALING IN GLIOBLASTOMA: WILD-TYPE EGFR PROMOTES INVASION WHILE EGFRvIII DRIVES PROTOTYPICAL SFK c-SRC ACTIVATION TO FOSTER ANGIOGENESIS

EGFR gene amplification is observed in upwards of 40% of glioblastoma (GBM) biopsies, and genetic aberration to EGFR at large has been described to occur in excess of 50%. Our lab has developed a clinically relevant in vivo xenograft model derived from patient biopsies in which we are able to accura...

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Detalhes bibliográficos
Main Authors: Eskilsson, Eskil, Røsland, Gro, Talasila, Krishna, Jahedi, Rosa, Leiss, Lina, Saed, Halala, Keunen, Olivier, Foerster, Sarah, Euskirchen, Philipp, Hossain, Jubayer, Taxt, Torfinn, Jirik, Radovan, Lund-Johansen, Morten, Enger, Per Øyvind, Ritter, Christoph, Niclou, Simone, Bjerkvig, Rolf, Miletic, Hrvoje
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217848/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou238.10
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