O4.01 DISTINCT FUNCTIONAL ROLES OF WILD-TYPE EGFR AND ITS MUTANT EGFRVIII IN GLIOBLASTOMA DEVELOPMENT

The epidermal growth factor receptor (EGFR) is a well-known mediator of invasion, proliferation and survival of tumor cells. Amplification and associated overexpression of wild-type (wt) EGFR is the most common genetic alteration in primary glioblastoma (GBM), with a frequency of about 40-50%. Of th...

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Autors principals: Miletic, H., Rosland, G.V., Eskilsson, E., Vaelk, K., Keunen, O., Jahedi, R., Azuaje, F., Stieber, D., Foerster, S., Ritter, C.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Oral Presentations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185572/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou174.22
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