EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation

BACKGROUND: Amplification of the epidermal growth factor receptor (EGFR) and its mutant EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most frequent and most aggressive primary brain tumor. METHODS: In the present work, we analyzed the clonal evolution of these maj...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Eskilsson, Eskil, Rosland, Gro V., Talasila, Krishna M., Knappskog, Stian, Keunen, Olivier, Sottoriva, Andrea, Foerster, Sarah, Solecki, Gergely, Taxt, Torfinn, Jirik, Radovan, Fritah, Sabrina, Harter, Patrick N., Välk, Kristjan, Al Hossain, Jubayer, Joseph, Justin V., Jahedi, Roza, Saed, Halala S., Piccirillo, Sara G., Spiteri, Inma, Leiss, Lina, Euskirchen, Philipp, Graziani, Grazia, Daubon, Thomas, Lund-Johansen, Morten, Enger, Per Øyvind, Winkler, Frank, Ritter, Christoph A., Niclou, Simone P., Watts, Colin, Bjerkvig, Rolf, Miletic, Hrvoje
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Basic and Translational Investigation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791772/
https://ncbi.nlm.nih.gov/pubmed/27286795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now113
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg