TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma

BACKGROUND: The ligands of mitochondrial translocator protein (TSPO) have been widely used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in vivo and its role in glioma tumorigenesis remain elusive. METHODS: TSPO knockout xenograft and spontaneous mouse glioma mode...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Fu, Yi, Wang, Dongdong, Wang, Huaishan, Cai, Menghua, Li, Chao, Zhang, Xue, Chen, Hui, Hu, Yu, Zhang, Xuan, Ying, Mingyao, He, Wei, Zhang, Jianmin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7442372/
https://ncbi.nlm.nih.gov/pubmed/31563962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz183
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