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The ectodomain of matriptase-2 plays an important nonproteolytic role in suppressing hepcidin expression in mice
Matriptase-2 (MT2), encoded by TMPRSS6, is a membrane-anchored serine protease that plays a key role in suppressing hepatic hepcidin expression. MT2 is synthesized as a zymogen and undergoes autocleavage for activation. Previous studies suggest that MT2 suppresses hepcidin by cleaving hemojuvelin an...
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| Publicado no: | Blood |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7441170/ https://ncbi.nlm.nih.gov/pubmed/32384154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005222 |
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