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The catalytic, stem, and transmembrane portions of matriptase-2 are required for suppressing the expression of the iron-regulatory hormone hepcidin

Matriptase-2 (MT2) is a type-II transmembrane, trypsin-like serine protease that is predominantly expressed in the liver. It is a key suppressor for the expression of hepatic hepcidin, an iron-regulatory hormone that is induced via the bone morphogenetic protein signaling pathway. A current model pr...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Mao, Peizhong, Wortham, Aaron M., Enns, Caroline A., Zhang, An-Sheng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369271/
https://ncbi.nlm.nih.gov/pubmed/30559294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006468
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