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Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models
We have previously shown that the incomplete splicing of exon 1 to exon 2 of the HTT gene results in the production of a small polyadenylated transcript (Httexon1) that encodes the highly pathogenic exon 1 HTT protein. There is evidence to suggest that the splicing factor SRSF6 is involved in the me...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7441155/ https://ncbi.nlm.nih.gov/pubmed/32820193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71111-w |
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