Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model

Huntington’s disease is caused by the expansion of a CAG repeat within exon 1 of the HTT gene, which is unstable, leading to further expansion, the extent of which is brain region and peripheral tissue specific. The identification of DNA repair genes as genetic modifiers of Huntington’s disease, tha...

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Dades bibliogràfiques
Publicat a:Brain Commun
Autors principals: Landles, Christian, Milton, Rebecca E, Ali, Nadira, Flomen, Rachel, Flower, Michael, Schindler, Franziska, Gomez-Paredes, Casandra, Bondulich, Marie K, Osborne, Georgina F, Goodwin, Daniel, Salsbury, Grace, Benn, Caroline L, Sathasivam, Kirupa, Smith, Edward J, Tabrizi, Sarah J, Wanker, Erich E, Bates, Gillian P
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425396/
https://ncbi.nlm.nih.gov/pubmed/32954323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa066
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