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The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
We have previously shown that exon 1 of the huntingtin gene does not always splice to exon 2 resulting in the production of a small polyadenylated mRNA (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein. The level of this read-through product is proportional to CAG repeat length and is...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5431000/ https://ncbi.nlm.nih.gov/pubmed/28465506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01510-z |
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