טוען...
Regulatory mechanisms of incomplete huntingtin mRNA splicing
Huntington’s disease is caused by a CAG repeat expansion in exon 1 of the HTT gene. We have previously shown that exon 1 HTT does not always splice to exon 2 producing a small transcript (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein. The mechanisms by which this incomplete splicin...
שמור ב:
| הוצא לאור ב: | Nat Commun |
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| Main Authors: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6160442/ https://ncbi.nlm.nih.gov/pubmed/30262848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06281-3 |
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