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Regulatory mechanisms of incomplete huntingtin mRNA splicing
Huntington’s disease is caused by a CAG repeat expansion in exon 1 of the HTT gene. We have previously shown that exon 1 HTT does not always splice to exon 2 producing a small transcript (HTTexon1) that encodes the highly pathogenic exon 1 HTT protein. The mechanisms by which this incomplete splicin...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6160442/ https://ncbi.nlm.nih.gov/pubmed/30262848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06281-3 |
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