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Extracellular glutamate and IDH1(R132H) inhibitor promote glioma growth by boosting redox potential
PURPOSE: Somatic mutations of the isocitrate dehydrogenase 1 (IDH1) gene, mostly substituting Arg132 with histidine, are associated with better patient survival, but glioma recurrence and progression are nearly inevitable, resulting in disproportionate morbidity and mortality. Our previous studies d...
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| Publicado en: | J Neurooncol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7440756/ https://ncbi.nlm.nih.gov/pubmed/32020473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03359-w |
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