O4.08 AGI5198, AN INHIBITOR OF IDH1R132H, PROTECTS IDH1R132H HCT116 CELLS AGAINST IRRADIATION

BACKGROUND: IDH1(R132H) mutations are both inaugural events in the formation of glioma and associated with prolonged glioma patient survival. The IDH1(R132H) mutation confers a neo-enzymatic function that results in accumulation of the oncometabolite D-2-hydroxyglutarate (D-2HG), which promotes glio...

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Main Authors: Molenaar, R.J., Dimitrakopoulou, D., Stap, J., Bleeker, F.E., Van Noorden, C.J.F.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Oral Presentations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185649/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou174.29
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