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A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells

Extracellular hydrogen peroxide can induce oxidative stress, which can cause cell death if unresolved. However, the cellular mediators of H(2)O(2)-induced cell death are unknown. We determined that H(2)O(2)-induced cytotoxicity is an iron-dependent process in HAP1 cells and conducted a CRISPR/Cas9-b...

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Библиографические подробности
Опубликовано в: :mBio
Главные авторы: Chidawanyika, Tamutenda, Mark, Kenneth M. K., Supattapone, Surachai
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439486/
https://ncbi.nlm.nih.gov/pubmed/32788383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01704-20
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