Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening

BACKGROUND: Genome-wide CRISPR-Cas9 dropout screens can identify genes whose knockout affects cell viability. Recent CRISPR screens detected thousands of essential genes required for cellular survival and key cellular processes; however discovering novel lineage-specific genetic dependencies from th...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Kiessling, Michael K., Schuierer, Sven, Stertz, Silke, Beibel, Martin, Bergling, Sebastian, Knehr, Judith, Carbone, Walter, de Vallière, Cheryl, Tchinda, Joelle, Bouwmeester, Tewis, Seuwen, Klaus, Rogler, Gerhard, Roma, Guglielmo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016932/
https://ncbi.nlm.nih.gov/pubmed/27613601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-3042-2
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