Dynamic allosteric communication pathway directing differential activation of the glucocorticoid receptor

Allosteric communication within proteins is a hallmark of biochemical signaling, but the dynamic transmission pathways remain poorly characterized. We combined NMR spectroscopy and surface plasmon resonance to reveal these pathways and quantify their energetics in the glucocorticoid receptor, a tran...

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Vydáno v:Sci Adv
Hlavní autoři: Köhler, C., Carlström, G., Gunnarsson, A., Weininger, U., Tångefjord, S., Ullah, V., Lepistö, M., Karlsson, U., Papavoine, T., Edman, K., Akke, M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439413/
https://ncbi.nlm.nih.gov/pubmed/32832645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb5277
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